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Continuous monitoring is the next frontier in diagnostics.
The shift from point-in-time testing to real-time, wearable sensing is underway and the molecular recognition layer is the bottleneck. Pentabind solves it.
Metabolic health
Continuous biomarker sensing to guide precision dosing in metabolic care.
Hormonal health
Precision sensing resources that reveal hormonal changes as they happen.
Drug monitoring
High-value resources for continuous therapeutic monitoring and dose adjustment.
You'll license commercial-grade aptamer assets, engineered for sensing and delivered with a full data package affinity, specificity, limit of detection, and performance in the relevant application format.
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A binder is not an asset.
Most aptamer programmes begin the same way: find something that binds. But binding in buffer is the easy part. Despite more than a decade of effort across the field, very few aptamers have ever reached commercially viable, application-ready performance. Getting there takes a fundamentally different approach.
Binds in buffer. Fails in the field.
Optimised under controlled conditions. Performance degrades in biological matrices. No validation against real application requirements.
- Binds in phosphate buffer
- Untested in blood or ISF
- Binds in buffer in the lab
- Untested in matrix of interest e.g sweat, blood or ISF
Designed to perform. Delivered with proof.
Every SenseReady™ asset is engineered with required performance characteristics built in - validated to the application standard, in the matrix that matters.
- Validated in biological matrix
- Selectivity confirmed vs. interferents
- Structural switching maintained
- Delivered with full datasheet
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A decade of effort, and the industry still counts commercially viable aptamers on one hand.
The gap between a binder and an asset isn't a small step. It's the difference between a proof-of-concept and a product that works.
We generate unique training data, design and validate aptamers in our own lab, and feed the results back into the model a compounding loop competitors can't replicate.
AI models trained on proprietary data design candidates with the characteristics the application needs.
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Wet-lab testing in real matrices, blood, sweat, body temperature, proves performance, not just binding.
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Every result improves the model. Not SELEX-only. Not AI-only. A full closed feedback loop.
300×
more high-affinity hits
~22 days
to first confirmed binders
~75–100 days
to application-ready assets
Delivered ready, not almost ready.
SenseReady™ assets aren't handed over as starting points. Every asset is delivered with performance characteristics built in, validated against real application requirements, and accompanied by full supporting data - so your team can move directly to integration.
Progesterone Aptamer Asset
Performance Summary
Binding affinity, selectivity, and in-matrix behavior prepared for application review.
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1–200 ng/mL
>50x
Confirmed
Application
Wearable / CGM
Validation matrix
ISF + Sweat
Mechanism
Electrochemical
Licensing
Available
Performance characteristics built in
Affinity, selectivity, and structural switching engineered to spec, not optimised post-delivery.
Validated to application requirements
Tested in the matrix and at the concentration range your device will actually see.
Delivered with supporting data
Every asset ships with a full technical datasheet; the document your integration teams need.
Most aptamers were discovered as research binders. They bind in a lab; but were never built for sensing, device integration, real biological matrices, or commercial deployment.
PentaBind engineers aptamers for the final application from the start. Binding is necessary, but not sufficient.
Not an in-buffer binder. Not literature sequences. SenseReady™ assets validated to perform in blood, at body temperature, inside the actual device.
A decade ago, our founder built a diagnostics company that depended on aptamers but couldn't source ones that worked outside the lab. PentaBind exists to solve exactly that problem, for the whole industry.
Rory Ryan
built by people who have sat in your seat
What our customers say
"We're always looking for ways to accelerate our progress. Another major diagnostics company recommended we contact you"
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"This should make our life extremely easy. What we'll basically be doing is substituting our commercial aptamers with your aptamers"
"Your approach takes a huge amount of complexity off our plate. It makes our life much easier."
