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AI Powered Aptamer Design

Unlock Your Potential with Precision Aptamer Solutions in 2024

We design aptamers that work

Our goal is to empower the aptamer industry to help society. We understand that to make a commercially viable aptamer-product you need more than just aptamer binding affinity. Using our AI and integrated wet-laboratory platform we design high-performance aptamers with all the characteristics needed to get a product on the market.

#1

PentaBind's AI platform designs aptamers with multiple characteristics in one step

Binding Affinity

Site targeting

Specificity

Stability

Conformational Folding

Additional characteristics in development

>50% improved performance in 50% less time

Our proprietary AI-based platform applies a powerful Generative AI approach to rapidly design aptamers that have a higher performance when compared to aptamers developed in physical laboratory experiments such as SELEX.
 

#2

Our AI identifies poor binders and creates completely new, higher performing aptamers

Our AI is highly creative and can generate completely new sequences not seen before in any training dataset. The process is much more powerful than bioinformatics analysis which can only select binders based upon abundance from an existing dataset of aptamer sequences.

#3

Predicted Affinity Score Distributions.jpg

#4

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Reducing the search space to improve success rates

Our AI reduces the aptamer search space from

1,298,074,214,633,706,907,132,624,082,305,024 (4^55)

to

17,179,869,184 (4^17) candidate sequences to find you better aptamers

(assuming an aptamer sequence of 55 nucleotides)

Our Services

1

SELEX Optimisation

Suitable if you already have an in-house wet-laboratory SELEX process. Provide us with initial data from your SELEX experiments and our AI will generate new and optimised aptamer library designs you can use in your SELEX campaigns to find better binders and reduce time by >50%

2

Aptamer Design

Suitable if you don't have an in-house SELEX process. Provide us with details about your target of interest and our AI will generate a shortlist of new and optimised aptamer sequences to bind to that target. We can optimise for binding, specificity, conformational folding and other application relevant characteristics.

3

SELEX Convergence

Free and unlimited usage of this tool for 2 months

Suitable if you already have in-house SELEX process. Upload your SELEX data and PentaBind's AI will identify if your SELEX has enrichment, no strings attached.

See Terms of Use for more information.

PentaBind supported us to find aptamers with higher binding affinity compared to the original [manually designed] sequences and did this in less than half the time and cost of manual experiments"

PentaBind customer

SELEX Optimisation

PentaBind provides optimised and customised aptamer libraries for your SELEX pipeline.

You provide SELEX fastq data to PentaBind

This data should include at least one round of SELEX. If you desire, you can also provide PentaBind with existing candidates you'd like to be optimised. If you desire, you can provide PentaBind with a list of protein targets to avoid.

2

AI Computation

In a process that requires only 10-48 hours, PentaBind's AI platform reduces the sequence space significantly and creates a library of new sequences not included in the original SELEX data.

3

PentaBind provides optimised SELEX libraries to you

PentaBind provides to you:

  • A list of optimised sequences (AI Optimised Library and N-Library representation)

  • An interactive bioinformatics and AI HTML report


Aptamer Design

PentaBind provides a shortlist of aptamers design to bind to your target of interest.

You provide target information to PentaBind

Provide details about the small molecule or protein target of interest (such as amino acid sequence). If you desire, you can also provide PentaBind with existing candidates you'd like to be optimised. If you desire, you can provide PentaBind with a list of protein targets to avoid.

2

AI Computation

In a process that requires only 10-48 hours, PentaBind's AI platform reduces the sequence space significantly and creates a shortlist of new sequences.

3

PentaBind provides a shortlist of aptamer sequences to you

PentaBind provides to you:

  • A list of optimised sequences (AI Optimised Library and N-Library representation)

  • An interactive bioinformatics and AI HTML report


Contact Us

Contact Us

Address

Scale Space, 58 Woodlane, White City, London, United Kingdom, W12 7RZ

Contact

  • LinkedIn

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