We design aptamers that work
Our goal is to empower the aptamer industry to help society. We understand that to make a commercially viable aptamer-product you need more than just aptamer binding affinity. Using our AI and integrated wet-laboratory platform we design high-performance aptamers with all the characteristics needed to get a product on the market.
#1
PentaBind's AI platform designs aptamers with multiple characteristics in one step
Binding Affinity
Site targeting
Specificity
Stability
Conformational Folding
Additional characteristics in development
>50% improved performance in 50% less time
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Our proprietary AI-based platform applies a powerful Generative AI approach to rapidly design aptamers that have a higher performance when compared to aptamers developed in physical laboratory experiments such as SELEX.
#2
Our AI identifies poor binders and creates completely new, higher performing aptamers
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Our AI is highly creative and can generate completely new sequences not seen before in any training dataset. The process is much more powerful than bioinformatics analysis which can only select binders based upon abundance from an existing dataset of aptamer sequences.
#3
#4
Reducing the search space to improve success rates
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Our AI reduces the aptamer search space from
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1,298,074,214,633,706,907,132,624,082,305,024 (4^55)
to
17,179,869,184 (4^17) candidate sequences to find you better aptamers
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(assuming an aptamer sequence of 55 nucleotides)
Our Services
1
SELEX Optimisation
Suitable if you already have an in-house wet-laboratory SELEX process. Provide us with initial data from your SELEX experiments and our AI will generate new and optimised aptamer library designs you can use in your SELEX campaigns to find better binders and reduce time by >50%
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2
Aptamer Design
Suitable if you don't have an in-house SELEX process. Provide us with details about your target of interest and our AI will generate a shortlist of new and optimised aptamer sequences to bind to that target. We can optimise for binding, specificity, conformational folding and other application relevant characteristics.
SELEX Optimisation
PentaBind provides optimised and customised aptamer libraries for your SELEX pipeline.
1
You provide SELEX fastq data to PentaBind
This data should include at least one round of SELEX. If you desire, you can also provide PentaBind with existing candidates you'd like to be optimised. If you desire, you can provide PentaBind with a list of protein targets to avoid.
2
AI Computation
In a process that requires only 10-48 hours, PentaBind's AI platform reduces the sequence space significantly and creates a library of new sequences not included in the original SELEX data.
3
PentaBind provides optimised SELEX libraries to you
PentaBind provides to you:
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A list of optimised sequences (AI Optimised Library and N-Library representation)
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An interactive bioinformatics and AI HTML report

Aptamer Design
PentaBind provides a shortlist of aptamers design to bind to your target of interest.
1
You provide target information to PentaBind
Provide details about the small molecule or protein target of interest (such as amino acid sequence). If you desire, you can also provide PentaBind with existing candidates you'd like to be optimised. If you desire, you can provide PentaBind with a list of protein targets to avoid.
2
AI Computation
In a process that requires only 10-48 hours, PentaBind's AI platform reduces the sequence space significantly and creates a shortlist of new sequences.
3
PentaBind provides a shortlist of aptamer sequences to you
PentaBind provides to you:
-
A list of optimised sequences (AI Optimised Library and N-Library representation)
-
An interactive bioinformatics and AI HTML report

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