Platform

Application-ready aptamer assets, ready to license.

The portfolio

Browse the portfolio.

What you can license, right now. Four asset families for the V1 launch, each a SenseReady™ standard. More assets in development across our sensing categories.

Sensor ready
Clinical range
0.01-0.6 ng/mL

Estradiol asset family

Licensing available
Sensor ready
Clinical range
0.1-25 ng/ml

Progesterone asset family

Licensing available
Sensor ready
Clinical range
0.05-1.8 mg/mL

Lactate asset family

Licensing available
Sensor ready
Clinical range
5-100 μg/mL

Creatinine asset family

Licensing available
The SenseReady™ difference

Not an in-buffer binder. A finished aptamer asset.

Performance engineered in

Designed against multiple application-critical requirements, not binding alone.

Developed upfront

PentaBind self-funds design and validation before licensing.

Licensed with evidence

Selected partners license a defined aptamer asset supported by a characterised performance profile and application-relevant matrix data.

SenseReady™ is

Multifunctional by design. Ready for continuous sensing.

SenseReady™ aptamers are engineered and benchmarked across the multiple capabilities continuous sensors demand, from affinity and specificity to biofluid compatibility, stability and reversible switching.

SenseReady™ Technical Datasheet

Progesterone Aptamer Asset

SR-PRO-004
Application-ready asset
Wearable / CGM
Illustrative performance data

Performance Summary

Binding affinity, selectivity, and in-matrix behavior prepared for application review.

Validated Operating Range

1–200 ng/mL

Selectivity Vs. Cortisone

>50x

In-Matrix Performance (ISF)

Confirmed

Application

Wearable / CGM

Validation matrix

ISF + Sweat

Mechanism

Electrochemical

Licensing

Available

Binding affinity

Binding strength engineered for target concentrations in the intended biofluid.

Selectivity

Discriminates the target from structurally similar molecules and other potential interferents.

Biofluid compatibility

Maintains functional performance in relevant matrices such as ISF, sweat, saliva or serum.

Functional stability

Retains its structure and performance under intended operating and storage conditions.

Reversible binding

Repeatedly binds and releases the target, enabling dynamic rather than single-point measurement.

Selected characteristics from the full SenseReady™ performance profile.

Beyond Binding

Binding is only the starting point.
Real-world sensing demands more.

Conventional aptamer programmes typically conclude once target binding has been demonstrated. SenseReady™ closes the gap between binder discovery and device integration.

What has been demonstrated
Where it has been tested
How it has been developed
Development stage
Where the partner begins
How it is accessed

In-buffer Binder

Conventional discovery output
Target binding
Buffer or controlled laboratory conditions
Against a binding-led specification
Discovery-stage research output
Aptamer optimisation and functionalisation
Commissioned discovery programme

SenseReady™ Aptamer

Application-ready · TRL 5-6
Functional sensing behaviour
Intended biofluid or biological matrix
Against a multi-characteristic sensing specification
Characterised asset available for licensing
Device integration and partner validation
Pre-developed asset licensing
The commercial viability test

Is your aptamer commercially viable?

Binding alone is not enough. An application-ready aptamer must perform across three levels of validation:

01 · Molecular performance
  • Affinity matched to the target range
  • Selectivity against close analogues
  • Reversible binding and switching
02 · Intended biofluid
  • Matrix compatibility
  • Functional stability
  • Relevant operating conditions
03 · Sensor integration
  • Detectable signal response
  • Repeatability and reproducibility
  • Continuous cycling performance
View a sample datasheet
Before starting another aptamer programme

Teams have pursued aptamer-based sensing for more than a decade. What makes your approach more likely to succeed?

The device concept is rarely the only challenge. A recurring bottleneck is access to aptamers that combine multiple sensing-critical characteristics in a single molecule.
AI trained on conventional selection data may find in-buffer binders faster, but it cannot reliably optimise characteristics the data does not capture. That is why PentaBind built its own proprietary, multi-characteristic sequence–function dataset.
The multi-characteristic platform behind SenseReady™

The multi-characteristic platform behind SenseReady™

Built on five years of proprietary sequence–function data, the platform combines predictive design with iterative wet-lab validation. It doesn’t simply accelerate conventional discovery, it engineers aptamers against multiple application requirements simultaneously.

01
Wet-lab data

Proprietary, multi-characteristic sequence–function measurements.

02
Dataset expansion

Each cycle expands and strengthens the proprietary training dataset.

03
Performance feedback

Experimental results guide optimisation and the next design cycle.

04
 Model learning

AI learns how sequence and structure influence molecular performance.

05
Candidate design

New sequences are designed against a multi-characteristic target profile.

06
Wet-lab validation

Candidates are tested against application-relevant performance criteria.

300×

more high-affinity hits

~22 days

to first confirmed binders

~75–100 days

to application-ready assets

The opportunity

What our customers say

Principal Chemist
F500 Company
"We're always looking for ways to accelerate our progress. Another major diagnostics company recommended we contact you"
CEO
Continuous hormone sensing scale-up
"This should make our life extremely easy. What we'll basically be doing is substituting our commercial aptamers with your aptamers"
Founder
Women's Health wearable
"Your approach takes a huge amount of complexity off our plate. It makes our life much easier."
It starts with selecting a target

The practical path to a license.

01

Select a target

Explore the portfolio or nominate a target for the SenseReady™ roadmap.

02

Apply for licensing

We assess each partner’s commercial, technical and regulatory plan, including reimbursement where applicable.

03

Reserve and license an asset

Selected partners reserve an asset within the target family and license a defined aptamer.

Why PentaBind exists

Built by someone who's sat in your seat.

Every SenseReady™ asset is already developed, you pay licence fees only after the asset has been validated against its agreed specification.

  • Founder background in diagnostics, sourced aptamers that failed outside the lab
  • PentaBind built to solve that exact problem for the industry
  • Assets designed, validated and delivered before any conversation starts
Trusted by FS500 and VC-backed scale-ups · backed by leading programs